Causal determinants of gout in 614,000 adults: A two-sample Mendelian randomization study of dietary, lifestyle, and metabolic traits.

doi:10.1097/MD.0000000000050619

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Article

Causal determinants of gout in 614,000 adults: A two-sample Mendelian randomization study of dietary, lifestyle, and metabolic traits.

Medicine - 11 Sept 2026

Jareebi Mohammad A

Abstract excerpt

Gout affects over 55 million people worldwide, with prevalence projected to rise by 70% by 2050. Although observational studies have implicated several dietary, lifestyle, and metabolic risk factors, causal relationships remain uncertain because of confounding and reverse causation. Univariable and multivariable two-sample Mendelian randomization (MR) analyses were performed using genome-wide association data...

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Topics

Gout
Humans
Mendelian Randomization Analysis
Life Style
Diet
Genome-Wide Association Study
Body Mass Index

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

United Kingdom

Adult

Risk Factors

Female

Polymorphism, Single Nucleotide

Male

UK Biobank

Source

Open in PubMed Open full text

Identifiers

PMID: 42736797
DOI: 10.1097/MD.0000000000050619
PMCID: PMC13574422

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