Article
Cone deactivation kinetics and GRK1/GRK7 expression in enhanced S cone syndrome caused by mutations in NR2E3.
Investigative ophthalmology & visual science - 1 Mar 2003
Cideciyan Artur V, Jacobson Samuel G, Gupta Nisha, Osawa Shoji, Locke Kristin G, Weiss Ellen R, Wright Alan F, Birch David G, Milam Ann H
Abstract excerpt
PURPOSE: To determine the relationship between cone deactivation kinetics in patients with the enhanced S cone syndrome (ESCS) caused by mutations in NR2E3 and the immunoreactivity to G-protein-coupled receptor kinase 1 (GRK1) and GRK7. METHODS: Electroretinogram (ERG) photoresponses were used to investigate activation kinetics of cones with a model of cone phototransduction. Deactivation kinetics of cones after...
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