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Article

Visual consequences of molecular changes in the guanylate cyclase-activating protein.

Investigative ophthalmology & visual science - 28 Mar 2014

Stockman Andrew, Henning G Bruce, Moore Anthony T, Webster Andrew R, Michaelides Michel, Ripamonti Caterina

Abstract excerpt

PURPOSE: We characterized and modeled changes in visual performance associated with a Tyr99Cys mutation in guanylate cyclase-activating protein-1 (GCAP1) in four family members aged between 39 and 55 years old. Guanylate cyclase and its activating protein are molecules in the visual transduction pathway that restore cyclic GMP (cGMP) following its light-activated hydrolysis. The mutation causes an excess of cGMP...

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PMID: 24557353
DOI: 10.1167/iovs.13-13682

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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