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Article

Human photoreceptor outer segments shorten during light adaptation.

Investigative ophthalmology & visual science - 1 May 2013

Abràmoff Michael D, Mullins Robert F, Lee Kyungmoo, Hoffmann Jeremy M, Sonka Milan, Critser Douglas B, Stasheff Steven F, Stone Edwin M

Abstract excerpt

PURPOSE: Best disease is a macular dystrophy caused by mutations in the BEST1 gene. Affected individuals exhibit a reduced electro-oculographic (EOG) response to changes in light exposure and have significantly longer outer segments (OS) than age-matched controls. The purpose of this study was to investigate the anatomical changes in the outer retina during dark and light adaptation in unaffected and Best disease...

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Topics

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Share to Adaptation, Ocular
Share to Dark Adaptation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrooculography

Share to Imaging, Three-Dimensional

Share to Phagocytosis

Share to Retinal Pigment Epithelium

Share to Tomography, Optical Coherence

Share to Vitelliform Macular Dystrophy

Source

Open in PubMed Open full text

Identifiers

PMID: 23633665
DOI: 10.1167/iovs.13-11812
PMCID: PMC3668803

Genes

BEST1
RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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