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Article

Mammalian SIRT6 Represses Invasive Cancer Cell Phenotypes through ATP Citrate Lyase (ACLY)-Dependent Histone Acetylation.

Genes - 21 Sept 2021

Zheng Wei, Tasselli Luisa, Li Tie-Mei, Chua Katrin F

Abstract excerpt

The modulation of dynamic histone acetylation states is key for organizing chromatin structure and modulating gene expression and is regulated by histone acetyltransferase (HAT) and histone deacetylase (HDAC) enzymes. The mammalian SIRT6 protein, a member of the Class III HDAC Sirtuin family of NAD+-dependent enzymes, plays pivotal roles in aging, metabolism, and cancer biology. Through its site-specific histone...

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PMID: 34573442
DOI: 10.3390/genes12091460
PMCID: PMC8466468

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