Article
Association of the methylation of age-related epigenetic marker ELOVL2 with neurophysiological alterations and immunosenescence during aging and its modulation by the APOE genotype.
Frontiers in immunology - 1 Jan 2026
Ponomareva Natalya V, Kuznetsova Irina L, Petrova Viktoria, Andreeva Tatiana V, Protasova Maria S, Konovalov Rodion N, Krotenkova Marina, Malina Daria D, Kolesnikova Ekaterina, Kanavets Elena, Kuprianova Daria, Mitrofanov Andrey, Vavilova Julia D, Boyko Anna A, Kovalenko Elena I, Sapozhnikov Alexander M, Fokin Vitaly F, Illarioshkin Sergey N, Rogaev Evgeny I
Abstract excerpt
Background: DNA methylation of the ELOVL2 (Elongation of Very Long Chain Fatty Acids Protein 2) promoter is one of the most robust molecular biomarkers for chronological age; however, whether ELOVL2 plays a functional role in brain aging and immunosenescence, and whether the APOE genotype modulates these effects, has not been fully explored. This study investigated the associations among ELOVL2 methylation, APOE...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.