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Article

The Genetic and Transcriptomic Nexus of Age-Related Hearing Loss and Alzheimer's Disease.

Genes - 30 Jun 2026

Deng Kaige, Deng Xu, Li Siying, Fang Shubin, Wei Fanqin

Abstract excerpt

Introduction: Despite the recognized association between age-related hearing loss (ARHL) and Alzheimer's disease (AD), the genetic relationship and shared transcriptional mechanisms between them remain largely unexplored. Methods: We systematically investigated the ARHL-AD axis using a multi-layered genomic strategy, incorporating causal inference, cis-eQTL mediation, Bayesian colocalization, and independent...

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PMID: 42510815
DOI: 10.3390/genes17070776
PMCID: PMC13409600

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