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Article

Integrative multi-dataset analysis identifies immune-inflammatory hub genes as diagnostic biomarkers and therapeutic targets for age-related hearing loss.

Hearing research - 1 Dec 2025

Luo Xiaoqin, Yuan Wei, Liu Jun, Zhang Chanyuan, Li Chao, Qin Gang

Abstract excerpt

Age-related hearing loss (ARHL) is a common neurodegenerative disorder in the elderly, but its molecular mechanisms and diagnostic biomarkers remain unclear. Here, by using the GSE49543 dataset (n = 40, Affymetrix microarray) from the Gene Expression Omnibus (GEO) with limma, 17 ARHL-associated differentially expressed genes were identified, which were enriched in immune effector functions and the IL-17 signaling...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41100952
DOI: 10.1016/j.heares.2025.109448

Genes

CD68
LGALS3
MPEG1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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