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Article

Biological insights from multi-omic analysis of 31 genomic risk loci for adult hearing difficulty.

PLoS genetics - 1 Sept 2020

Kalra Gurmannat, Milon Beatrice, Casella Alex M, Herb Brian R, Humphries Elizabeth, Song Yang, Rose Kevin P, Hertzano Ronna, Ament Seth A

Abstract excerpt

Age-related hearing impairment (ARHI), one of the most common medical conditions, is strongly heritable, yet its genetic causes remain largely unknown. We conducted a meta-analysis of GWAS summary statistics from multiple hearing-related traits in the UK Biobank (n = up to 330,759) and identified 31 genome-wide significant risk loci for self-reported hearing difficulty (p < 5x10-8), of which eight have not been...

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PMID: 32986727
DOI: 10.1371/journal.pgen.1009025
PMCID: PMC7544108

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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