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Article

Validation of fracture-derived polygenic scores with FRAX for fracture risk prediction in postmenopausal women.

Archives of osteoporosis - 27 Jul 2026

Liu Anqi, Liu Jianing, Wu Qing

Abstract excerpt

We evaluated whether adding a genetic risk score derived from forearm fracture improves fracture prediction beyond standard clinical tools. Incorporation of GPS resulted in a small increase in time-dependent AUC, with improvement in NRI. Decision curve analysis suggested potential clinical benefit across certain threshold ranges. BACKGROUND: Previous studies have incorporated estimated bone mineral density...

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PMID: 42509442
DOI: 10.1007/s11657-026-01740-7
PMCID: PMC13408118

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