Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhanced fracture risk prediction: a novel multi-trait genetic approach integrating polygenic scores of fracture-related traits.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA - 1 Aug 2024

Xiao Xiangxue, Wu Qing

Abstract excerpt

The novel metaPGS, integrating multiple fracture-related genetic traits, surpasses traditional polygenic scores in predicting fracture risk. Demonstrating a robust association with incident fractures, this metaPGS offers significant potential for enhancing clinical fracture risk assessment and tailoring prevention strategies. INTRODUCTION: Current polygenic scores (PGS) have limited predictive power for fracture...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Bone Density

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Multifactorial Inheritance

Share to Osteoporotic Fractures

Share to Polymorphism, Single Nucleotide

Share to Risk Assessment

Share to Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 38713246
DOI: 10.1007/s00198-024-07105-5
PMCID: PMC11282140

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhanced fracture risk prediction: a novel multi-trait genetic approach integrating polygenic scores of fracture-related traits.PMID 38713246Read ↗

Validation of fracture-derived polygenic scores with FRAX for fracture risk prediction in postmenopausal women.Semantic proximity Read ↗

Multiple polygenic scores improve bone mineral density prediction in an independent sample of Caucasian women.Semantic proximity Read ↗

Genetics and the individualized prediction of fracture.Semantic proximity Read ↗

Improved prediction of fracture risk leveraging a genome-wide polygenic risk scoreSemantic proximity Read ↗

Prediction of Bone Mineral Density and Fragility Fracture by Genetic ProfilingSemantic proximity Read ↗

Enhanced osteoporotic fracture prediction in postmenopausal women using Bayesian optimization of machine learning models with genetic risk score.Semantic proximity Read ↗

BMD-Related Genetic Risk Scores Predict Site-Specific Fractures as Well as Trabecular and Cortical Bone Microstructure.Semantic proximity Read ↗

Genome-wide polygenic risk score for major osteoporotic fractures in postmenopausal women using associated single nucleotide polymorphisms.Semantic proximity Read ↗

Bayesian Genome-wide Polygenic Score Integration with FRAX for Enhanced Fracture Risk Prediction in Postmenopausal WomenSemantic proximity Read ↗

Prediction of Future Osteoporotic Fracture Occurrence by Genetic Profiling: A 6-Year Follow-Up Observational Study.Semantic proximity Read ↗

Individualized Assessment of Fracture Risk: Contribution of "Osteogenomic Profile".Semantic proximity Read ↗

Using a Polygenic Score to Predict the Risk of Developing Primary OsteoporosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.