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Article

Variability in performance of genetic-enhanced DXA-BMD prediction models across diverse ethnic and geographic populations: A risk prediction study.

PLoS medicine - 1 Aug 2024

Liu Yong, Meng Xiang-He, Wu Chong, Su Kuan-Jui, Liu Anqi, Tian Qing, Zhao Lan-Juan, Qiu Chuan, Luo Zhe, Gonzalez-Ramirez Martha I, Shen Hui, Xiao Hong-Mei, Deng Hong-Wen

Abstract excerpt

BACKGROUND: Osteoporosis is a major global health issue, weakening bones and increasing fracture risk. Dual-energy X-ray absorptiometry (DXA) is the standard for measuring bone mineral density (BMD) and diagnosing osteoporosis, but its costliness and complexity impede widespread screening adoption. Predictive modeling using genetic and clinical data offers a cost-effective alternative for assessing osteoporosis...

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PMID: 39213443
DOI: 10.1371/journal.pmed.1004451
PMCID: PMC11404845

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