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Prognostic Association of Handgrip-Defined Probable or Possible Sarcopenia Status and Polygenic Risk with 10-Year Fracture Incidence among Black, Hispanic, and White Women: A Women’s Health Initiative Study

2026-07-02

Abstract excerpt

<h4>Purpose</h4> The Fracture Risk Assessment Tool (FRAX) excludes objective skeletal muscle health and genetic variables. We evaluated the prognostic associations of handgrip-defined probable/possible sarcopenia and genome-wide polygenic scores (GPS) with 10-year fracture risk, and their incremental predictive value beyond FRAX across racial/ethnic groups and GPS strata. <h4>Methods</h4> We analyzed 2,051 postm...

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Literature Corpus work
1e799bed-c7fa-5a74-a8da-f775237018d1
DOI
10.64898/2026.06.30.26356931
Open publication

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Prognostic Association of Handgrip-Defined Probable or Possible Sarcopenia Status and Polygenic Risk with 10-Year Fracture Incidence among Black, Hispanic, and White Women: A Women’s Health Initiative StudyDOI 10.64898/2026.06.30.26356931
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