Article

Bayesian Genome-wide Polygenic Score Integration with FRAX for Enhanced Fracture Risk Prediction in Postmenopausal Women

2025-06-07

Abstract excerpt

<h4>Importance</h4> Current fracture risk prediction tools, including the Fracture Risk Assessment Tool (FRAX), do not incorporate genetic risk factors limiting accuracy and contributing to misclassification and suboptimal care. <h4>Objective</h4> To develop and validate a novel genome-informed fracture risk assessment tool (Bayes-FRAX) integrating Bayesian genome-wide polygenic scores (GPS) into the established F...

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Literature Corpus work: 7fac3295-c8c7-5e49-94d4-28e0a06a7e55
DOI: 10.1101/2025.06.06.25329139

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