Evaluating the association of apolipoprotein E genotype and cognitive resilience in SuperAgers.

doi:10.1002/alz.71024

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Article

Evaluating the association of apolipoprotein E genotype and cognitive resilience in SuperAgers.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jan 2026

Durant Alaina, Mukherjee Shubhabrata, Lee Michael L, Choi Seo-Eun, Scollard Phoebe, Klinedinst Brandon S, Trittschuh Emily H, Mez Jesse, Farrer Lindsay A, Gifford Katherine A, Cruchaga Carlos, Hassenstab Jason, Naj Adam C, Wang Li-San, Johnson Sterling C, Engelman Corinne D, Kukull Walter A, Keene C Dirk, Saykin Andrew J, Cuccaro Michael L, Kunkle Brian W, Pericak-Vance Margaret A, Martin Eden R, Bennett David A, Barnes Lisa L, Schneider Julie A, Bush William S, Haines Jonathan L, Mayeux Richard, Vardarajan Badri N, Albert Marilyn S, Thompson Paul M, Jefferson Angela L, Crane Paul K, Dumitrescu Logan, Archer Derek B, Hohman Timothy J, Gaynor Leslie S

Abstract excerpt

INTRODUCTION: "SuperAgers" are oldest-old adults (ages 80+) whose memory performance more closely resembles middle-aged adults. The present study examined apolipoprotein E (APOE) allele frequency in non-Hispanic Black (NHB) and non-Hispanic White (NHW) SuperAgers compared to controls and Alzheimer's disease dementia cases. METHODS: In 18,080 participants from eight cohorts, harmonized clinical diagnostics and...

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PMID: 41542929
DOI: 10.1002/alz.71024
PMCID: PMC12809718

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APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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