Article

Cannabinoids Activate the Insulin Pathway to Modulate Mobilization of Cholesterol in <i>C. elegans</i>

2022-07-21

Abstract excerpt

The nematode Caenorhabditis elegans requires exogenous cholesterol to survive and its depletion leads to early development arrest. Thus, tight regulation of cholesterol storage and distribution within the organism is critical. Previously, we demonstrated that the endocannabinoid (eCB) 2-arachidonoylglycerol (2-AG) plays a key role in C. elegans modulating sterol mobilization, but the mechanism is unknown. Here w...

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Literature Corpus work: be00b64a-970b-574f-9e17-cdc11164aa30
DOI: 10.1101/2022.07.20.500754

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