Article
RB1 Loss as a Diagnostic Clue in a High-Grade Glioma With Pleomorphic and Pseudopapillary Features (HPAP): The First Reported Case With Spinal Metastasis and a Review of the Literature.
Pathology international - 1 Jul 2026
Aknar Furkan, Soylemez-Akkurt Tuce, Engin Zerk Pinar, Atalay Basak, Gürbüz Mehmet Sabri, Karaarslan Numan
Abstract excerpt
High-grade glioma with pleomorphic and pseudopapillary features (HPAP) is a recently described entity defined by a distinct DNA methylation signature, recurrent monosomy 13, and mutations in TP53, RB1, and NF1. Most cases are supratentorial with a relatively favorable prognosis. We report a 45-year-old woman who presented with a right cerebellar mass exhibiting striking histopathological heterogeneity comprising...
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