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Article

High-Grade Astrocytoma With Piloid Features: An Aggressive Clinicogenomic Entity Distinct From Pilocytic Astrocytoma.

Journal of Korean medical science - 9 Mar 2026

Kang Jeongwan, Kim Eric Eunshik, Lee Kwanghoon, Kim Seong-Ik, Park Jin Woo, Won Jae Kyung, Phi Ji Hoon, Kim Seung-Ki, Park Chul-Kee, Lee Hyunju, Park Sung-Hye

Abstract excerpt

BACKGROUND: High-grade astrocytoma with piloid features (HGAP) has recently emerged as an aggressive glioma entity with distinct molecular alterations, yet its clinicogenomic distinction from pilocytic astrocytoma (PA) remains to be fully elucidated. This study aims to clarify the clinical, pathological, and genomic differences between pediatric PA, adult PA, and HGAP, and to provide evidence supporting the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41807027
DOI: 10.3346/jkms.2026.41.e88
PMCID: PMC12976636

Genes

KRAS
BRAF
ATRX
CDKN2A
FGFR1
FGFR4
KIAA1549
NF1
PTPN11
TP53

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

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Research trail→

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High-Grade Astrocytoma With Piloid Features: An Aggressive Clinicogenomic Entity Distinct From Pilocytic Astrocytoma.PMID 41807027Read ↗

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Integrating Molecular Analyses with the 2021 WHO Classification for a More Precise Diagnosis of Adult Pilocytic AstrocytomasSemantic proximity Read ↗

High-Grade Astrocytoma with Piloid Features: A Dual Institutional Review of Imaging Findings of a Novel Entity.Semantic proximity Read ↗

Adult pilocytic astrocytoma in the molecular era: a comprehensive reviewSemantic proximity Read ↗

The histomolecular criteria established for adult anaplastic pilocytic astrocytoma are not applicable to the pediatric populationSemantic proximity Read ↗

Distinct Genetic Signatures among Pilocytic Astrocytomas Relate to Their Brain Region OriginSemantic proximity Read ↗

Expanded analysis of high-grade astrocytoma with piloid features identifies an epigenetically and clinically distinct subtype associated with neurofibromatosis type 1.Semantic proximity Read ↗

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The utility of DNA methylation analysis in elderly patients with pilocytic astrocytoma morphology.Semantic proximity Read ↗

Molecular alterations in the integrated diagnosis of pediatric glial and glioneuronal tumors: A single center experience.Semantic proximity Read ↗

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