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Article

Molecular profile of adult primary leptomeningeal gliomatosis aligns with glioblastoma, IDH-wildtype.

Brain pathology (Zurich, Switzerland) - 1 Jul 2025

Zhu Yi, Carabenciov Darin D, Johnson Derek R, Trejo-Lopez Jorge A, Nguyen Aivi T, Raghunathan Aditya, Lanzino Giuseppe, Ida Cristiane M, Zepeda-Mendoza Cinthya J, Dasari Surendra, Russler-Germain Emilie, Dahiya Sonika, Quezado Martha, Aldape Kenneth, Giannini Caterina

Abstract excerpt

Adult primary leptomeningeal gliomatosis (PLG) is a rare, rapidly progressive and fatal disease characterized by prominent leptomeningeal infiltration by a glial tumor without an identifiable parenchymal mass. The molecular profile of adult PLG has not been well-characterized. We report the clinical, pathological, and molecular findings of six adult PLG patients (five males and one female), median age 58 years....

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Source

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Identifiers

PMID: 39692003
DOI: 10.1111/bpa.13326
PMCID: PMC12145897

Genes

PLG
CDKN2A
CDK4
GLI1
NF1
PTEN
TERT
TP53

Provenance

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