Visual system function requires translational regulation of ATF4 by Hbs1-Pelo.

Abstract excerpt

Deletion mutations in the translation termination factor HBS1L result in progressive loss of vision in human patients, amongst other developmental anomalies. The etiology of vision defects seen with HBS1L deletion remains unknown. Here, we use the Drosophila visual system to demonstrate that the HBS1L ortholog, Hbs1, and its interaction partner, Pelo, are required for proper phototransduction. Hbs1 mutants showed...

Topics

• Animals
• Activating Transcription Factor 4
• Drosophila Proteins
• Humans
• Protein Biosynthesis
• Gene Expression Regulation