Article

Core Transcription Programs Controlling Injury-Induced Neurodegeneration of Retinal Ganglion Cells

2022-01-22

Abstract excerpt

<h4>SUMMARY</h4> Neurodegenerative diseases are characterized by neuronal death and regenerative failure. However, gene regulatory programs governing how initial neuronal injuries lead to neuronal death remain poorly understood. In adult mice, optic nerve crush (ONC) injury, which severs all axons of retinal ganglion cells (RGCs), results in massive death of axotomized RGCs and regenerative failure of survivors....

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Literature Corpus work: 3eff6260-6cd6-56de-a547-8fd355cf80ff
DOI: 10.1101/2022.01.20.477004

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