Article

Activation by statins unveils two putative agonist binding sites in the pore domain of TRPA1

2026-05-12

Abstract excerpt

TRPA1 is a non-selective cation channel that plays a crucial role in several pain and inflammatory conditions. Agents reducing membrane cholesterol decrease TRPA1 activation, but it remains unclear how cholesterol-lowering medications affect TRPA1 function. Given that TRPA1 is activated by a wide variety of chemicals, we explored whether statins have acute effects on this channel. We found that five commonly used...

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Identifiers and source

Literature Corpus work: 81242cd4-797d-5b35-8618-67090def211a
DOI: 10.64898/2026.05.08.723702

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