Article
Characterizing the role of Thr352 in the inhibition of the large conductance Ca2+-activated K+ channels by 1-[1-hexyl-6-(methyloxy)-1H-indazol-3-yl]-2-methyl-1-propanone.
The Journal of pharmacology and experimental therapeutics - 1 Aug 2010
Gordon Earl, Semus Simon F, Lozinskaya Irina M, Lin Zuojun, Xu Xiaoping
Abstract excerpt
Large conductance Ca(2+)-activated K(+) (BK) channels are known to be regulated by both intracellular Ca(2+) and voltage. Although BK channel modulators have been identified, there is a paucity of information regarding the molecular entities of this channel that govern interaction with blockers and activators. Using both whole-cell and single-channel electrophysiological studies we have characterized the possible...
Topics
- Amino Acid Sequence
- Amino Acid Substitution
- Animals
- CHO Cells
- Calcium
- Cricetinae
- Cricetulus
- Electric Conductivity
- Indazoles
- Large-Conductance Calcium-Activated Potassium Channels
- Models, Molecular
- Molecular Sequence Data