Long-read sequencing of single cell-derived melanoma sublines reveals divergent and parallel genomic and epigenomic evolutionary trajectories.

doi:10.1038/s41467-026-75172-9

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Article

Long-read sequencing of single cell-derived melanoma sublines reveals divergent and parallel genomic and epigenomic evolutionary trajectories.

Nature communications - 16 Jul 2026

Liu Yuelin, Goretsky Anton, Keskus Ayse G, Malikic Salem, Ahmad Tanveer, Gertz E Michael, Rashidi Mehrabadi Farid, Kelly Michael, Hernandez Maria O, Seibert Charlie, Caravaca Juan Manuel, Kline Kayla, Zhao Yongmei, Wu Ying, Shrestha Biraj, Tran Bao, Ghosh Arindam, Cui Xiwen, Sassano Antonella, Malik Laksh, Baker Breeana, Blauwendraat Cornelis, Billingsley Kimberley J, Burkett Sandra, Perez-Guijarro Eva, Merlino Glenn, Molloy Erin K, Sahinalp S Cenk, Day Chi-Ping, Kolmogorov Mikhail

Abstract excerpt

Tumor evolution is driven by various mutational processes, ranging from single-nucleotide variants (SNVs) to large structural variants (SVs) to dynamic shifts in DNA methylation. Current short-read sequencing methods struggle to accurately capture the full spectrum of these genomic and epigenomic alterations due to inherent technical limitations. To overcome that, here we introduce an approach to identify and...

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Identifiers

PMID: 42463712
DOI: 10.1038/s41467-026-75172-9
PMCID: PMC13493970

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