Article

Multi-modal single-cell and whole-genome sequencing of minute, frozen specimens to propel clinical applications

2022-02-13

Abstract excerpt

<h4>ABSTRACT</h4> Single-cell genomics are enabling technologies, but their broad clinical application remains challenging. We report an easily adaptable approach for single-cell transcriptome and T cell receptor (TCR)-sequencing, and matched whole-genome sequencing from tiny, frozen clinical specimens. We achieve similar quality and biological outputs while reducing artifactual signals compared to data from matc...

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Literature Corpus work: a754c9eb-a35f-5ed8-99e1-684de3a4e75f
DOI: 10.1101/2022.02.13.480272

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