Article
Comprehensive genomic analysis of primary malignant melanoma of the esophagus reveals similar genetic patterns compared with epithelium-associated melanomas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Nov 2022
Li Jingjing, Liu Bing, Ye Qing, Xiao Xiao, Yan Shi, Guan Wenyan, He Lu, Wang Changxi, Yu Zicheng, Tai Zaixian, Pei Shimei, Ma Yuanyuan, Li Shaolei, Wang Yaqi, Wu Nan
Abstract excerpt
Primary malignant melanoma of the esophagus (PMME) is an exceedingly rare disease with a poor prognosis. The etiology of PMME remains largely unknown and genetic characteristics are yet to be clarified, essential for identifying potential therapeutic targets and defining treatment guidelines. Here, we performed whole-exome sequencing on 47 formalin-fixed paraffin-embedded specimens from 18 patients with PMME,...
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