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Article

Disruption of the S1/S2 multibasic cleavage site attenuates infectious bronchitis virus, while S2' partially restores viral virulence and expands tissue tropism.

Journal of virology - 18 Aug 2026

Zhao Ye, Zhao Jun, Li Yingfei, Duan Linqing, Liang Rong, Huang Min, Zhao Jing, Zhang Guozhong

Abstract excerpt

Multibasic cleavage motifs play critical roles in envelope glycoprotein-mediated viral entry by serving as substrates for proprotein convertases like furin. The gamma-coronavirus infectious bronchitis virus (IBV) inherently possesses a conserved S1/S2 multibasic cleavage site (MBCS) within its S gene. Notably, the IBV Beaudette strain uniquely harbors an additional S2' MBCS, which extends its cellular tropism....

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Identifiers

PMID: 42405771
DOI: 10.1128/jvi.00614-26
PMCID: PMC13483448

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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