Article
Accumulation of mutations in nsp4, E, and the S2 subunit underlies mammalian cell tropism expansion and virulence attenuation of avian coronavirus.
PLoS pathogens - 1 Apr 2026
Li Yingfei, Zhang Xuehui, Liang Rong, Li Ruotong, Yang Ruihua, Zhang Liwei, Zhao Ye, Zhang Guozhong, Zhao Jing
Abstract excerpt
Infectious bronchitis virus (IBV), a Gammacoronavirus with strict host tropism, infects chickens and avian-derived primary cells but not mammalian cells. The classical Beaudette strain, isolated in the 1930s, is a well-established IBV strain capable of replicating in Vero cells. Although sporadic reports have described similar adaptation in other strains, the molecular mechanisms underlying IBV cell tropism...
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