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Article

The S2 Subunit of QX-type Infectious Bronchitis Coronavirus Spike Protein Is an Essential Determinant of Neurotropism.

Viruses - 22 Oct 2019

Cheng Jinlong, Zhao Ye, Xu Gang, Zhang Keran, Jia Wenfeng, Sun Yali, Zhao Jing, Xue Jia, Hu Yanxin, Zhang Guozhong

Abstract excerpt

Some coronaviruses (CoVs) have an extra furin cleavage site (RRKR/S, furin-S2' site) upstream of the fusion peptide in the spike protein, which plays roles in virion adsorption and fusion. Mutation of the S2' site of QX genotype (QX-type) infectious bronchitis virus (IBV) spike protein (S) in a recombinant virus background results in higher pathogenicity, pronounced neural symptoms and neurotropism when compared...

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Source

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Identifiers

PMID: 31652591
DOI: 10.3390/v11100972
PMCID: PMC6832359

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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