Article
Two mutations on S2 subunit were critical for Vero cell tropism expansion of infectious bronchitis virus HV80.
Veterinary microbiology - 1 Jul 2024
Jiang Yi, Cheng Xu, Gao Mingyan, Yu Yan, Dou Xinhong, Shen Haiyu, Tang Mengjun, Zhou Sheng, Peng Daxin
Abstract excerpt
Infectious bronchitis virus (IBV) restricts cell tropism. Except for the Beaudette strain, other IBVs cannot infect mammalian cell lines. The limited cell tropism of other IBVs has hindered IBV vaccine development and research on the mechanisms of IBV infection. A novel Vero cell-adapted strain, HV80, has been previously reported. In this study, we constructed recombinants expressing the chimeric S glycoprotein,...
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