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Article

Ancestral allele of DNA polymerase gamma modifies antiviral tolerance.

Nature - 1 Apr 2024

Kang Yilin, Hepojoki Jussi, Maldonado Rocio Sartori, Mito Takayuki, Terzioglu Mügen, Manninen Tuula, Kant Ravi, Singh Sachin, Othman Alaa, Verma Rohit, Uusimaa Johanna, Wartiovaara Kirmo, Kareinen Lauri, Zamboni Nicola, Nyman Tuula Anneli, Paetau Anders, Kipar Anja, Vapalahti Olli, Suomalainen Anu

Abstract excerpt

Mitochondria are critical modulators of antiviral tolerance through the release of mitochondrial RNA and DNA (mtDNA and mtRNA) fragments into the cytoplasm after infection, activating virus sensors and type-I interferon (IFN-I) response1-4. The relevance of these mechanisms for mitochondrial diseases remains understudied. Here we investigated mitochondrial recessive ataxia syndrome (MIRAS), which is caused by a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38570685
DOI: 10.1038/s41586-024-07260-z
PMCID: PMC11041766

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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