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Article

Dysregulated expression of lipid storage and membrane dynamics factors in Tia1 knockout mouse nervous tissue

22 Mar 2014

Abstract excerpt

During cell stress, the transcription and translation of immediate early genes are prioritized, while most other messenger RNAs (mRNAs) are stored away in stress granules or degraded in processing bodies (P-bodies). TIA-1 is an mRNA-binding protein that needs to translocate from the nucleus to seed the formation of stress granules in the cytoplasm. Because other stress granule components such as TDP-43, FUS,...

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PMID: 24659297
DOI: 10.1007/s10048-014-0397-x

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