Article
Depression-like episodes in mice harboring mtDNA deletions in paraventricular thalamus.
Molecular psychiatry - 1 Jan 2016
Kasahara T, Takata A, Kato T M, Kubota-Sakashita M, Sawada T, Kakita A, Mizukami H, Kaneda D, Ozawa K, Kato T
Abstract excerpt
Depression is a common debilitating human disease whose etiology has defied decades of research. A critical bottleneck is the difficulty in modeling depressive episodes in animals. Here, we show that a transgenic mouse with chronic forebrain expression of a dominant negative mutant of Polg1, a mitochondrial DNA (mtDNA) polymerase, exhibits lethargic behavioral changes, which are associated with emotional,...
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