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Research progress, challenges and perspectives on PNPLA3 and its variants in Liver Diseases

1 Jan 2021

Abstract excerpt

The human patatin-like phospholipase domain-containing 3 gene (PNPLA3) is highly expressed in liver and adipose tissue and encodes a transmembrane polypeptide chain containing 481 amino acids. The I148M variant of PNPLA3 is a single nucleotide polymorphism, which is related to a variety of liver and cardiovascular diseases and their complications (such as non-alcoholic fatty liver disease, liver fibrosis,...

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Endoplasmic Reticulum Stress and Disease
Glycosylation and Glycoproteins Research
Liver Disease Diagnosis and Treatment

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34476007
DOI: 10.7150/jca.57951

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Research progress, challenges and perspectives on PNPLA3 and its variants in Liver DiseasesPMID 34476007Read ↗

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PNPLA3 I148M variant and hepatocellular carcinoma: a common genetic variant for a rare disease.Semantic proximity Read ↗

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