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Article

Restoring cortical disinhibition improves Huntington's disease phenotypes.

Nature - 1 Jul 2026

Blumenstock Sonja, Arakelyan David, Del Grosso Nicholas, Schneider Sonja, Shao Yufeng, Gjoni Enida, Klein Rüdiger, Dudanova Irina, Komiyama Takaki

Abstract excerpt

Huntington's disease (HD) is a devastating movement disorder without a cure at present1. Although the monogenic basis of HD is well defined2, the complex downstream effects that underlie behavioural symptoms are poorly understood. These effects include cortical dysfunction3,4, yet the roles of specific cortical neuronal subtypes in HD symptoms remain largely unexplored. Here we used longitudinal in vivo...

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PMID: 42386967
DOI: 10.1038/s41586-026-10671-9
PMCID: PMC13421345

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