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Article

Hyperactivity and cortical disinhibition in mice with restricted expression of mutant huntingtin to parvalbumin-positive cells.

Neurobiology of disease - 1 Feb 2014

Dougherty S E, Hollimon J J, McMeekin L J, Bohannon A S, West A B, Lesort M, Hablitz J J, Cowell R M

Abstract excerpt

Recent evidence suggests that interneurons are involved in the pathophysiology of Huntington Disease (HD). Abnormalities in the function of interneurons expressing the calcium buffer parvalbumin (PV) have been observed in multiple mouse models of HD, although it is not clear how PV-positive interneuron dysfunction contributes to behavioral and synaptic deficits. Here, we use the cre-lox system to drive expression...

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Identifiers

PMID: 24121117
DOI: 10.1016/j.nbd.2013.10.002
PMCID: PMC3877729

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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