Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Relationship between Iron and LRRK2 in a 6-OHDA-Induced Parkinson's Disease Model.

International journal of molecular sciences - 13 Feb 2023

Jia Ruru, Liu Yanling, Shuai Ke, Zhou Cheng, Chen Lei, Zhu Li, Wu Xiao-Mei

Abstract excerpt

The pathogenesis of Parkinson's disease (PD) is very complex and still needs further exploration. Leucine-rich repeat kinase 2 (LRRK2) is associated with familial PD in mutant forms and sporadic PD in the wild-type form. Abnormal iron accumulation is found in the substantia nigra of PD patients, but its exact effects are not very clear. Here, we show that iron dextran exacerbates the neurological deficit and loss...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Models, Animal
Share to Dopaminergic Neurons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Share to Oxidopamine

Share to Parkinson Disease

Share to Substantia Nigra

Source

Open in PubMed Open full text

Identifiers

PMID: 36835121
DOI: 10.3390/ijms24043709
PMCID: PMC9964371

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Relationship between Iron and LRRK2 in a 6-OHDA-Induced Parkinson's Disease Model.PMID 36835121Read ↗

LRRK2 mutations: at the crossroads of dopamine, iron, and calcium imbalance in Parkinson's disease.Semantic proximity Read ↗

Novel druggable mechanism of Parkinson's disease: Potential therapeutics and underlying pathogenesis based on ferroptosisSemantic proximity Read ↗

The molecular mechanism of ferroptosis and its relationship with Parkinson's diseaseSemantic proximity Read ↗

The Parkinson’s disease associated Leucine-rich repeat kinase 2 affects expression of Transferrin receptor 1 and phosphorylation of key signaling proteins in human iPSC-derived dopaminergic neuronsSemantic proximity Read ↗

Parkinson’s disease LRRK2 mutations dysregulate iron homeostasis and promote oxidative stress and ferroptosis in human neurons and astrocytesSemantic proximity Read ↗

Iron Dysregulation in Parkinson’s Disease: Focused on the Autophagy–Lysosome PathwaySemantic proximity Read ↗

Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.Semantic proximity Read ↗

An LRRK2 variant blocks NCOA4 trafficking upon iron overload, leading to ferroptotic death.Semantic proximity Read ↗

LRRK2 enhances oxidative stress-induced neurotoxicity via its kinase activity.Semantic proximity Read ↗

JWA binding to NCOA4 alleviates degeneration in dopaminergic neurons through suppression of ferritinophagy in Parkinson's diseaseSemantic proximity Read ↗

The relevance of iron in the pathogenesis of Parkinson’s diseaseSemantic proximity Read ↗

Dopamine-iron homeostasis interaction rescues mitochondrial fitness in Parkinson’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.