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Article

RECQ4 arginine methylation suppresses single-stranded DNA gap accumulation at replication forks.

Nucleic acids research - 22 Jun 2026

Ma Ning, Xu Xiaohua, Espinoza Michael, Chang Chou-Wei, Shiozaki Yukari, Guo Zhigang, Izuagie Louis, Shen Binghui, Yang Yanzhong, Liu Yilun

Abstract excerpt

The role of protein arginine methylation in regulating transcription and RNA processing is well established, but its function in DNA replication remains poorly understood. In this study, we identify asymmetric dimethylarginine (aDMA) modification of the RECQ4 helicase as a key mechanism linking arginine methylation to replication control. Five arginine residues located within a glycine/arginine-rich region...

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Arginine
DNA Polymerase III
DNA Replication
DNA, Single-Stranded
Genomic Instability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein-Arginine N-Methyltransferases

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Identifiers

PMID: 42363758
DOI: 10.1093/nar/gkag655
PMCID: PMC13309783

Genes

MCM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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