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Article

Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control.

Genes & development - 15 Mar 2005

Boisvert François-Michel, Déry Ugo, Masson Jean-Yves, Richard Stéphane

Abstract excerpt

The role of protein arginine methylation in the DNA damage checkpoint response and DNA repair is largely unknown. Herein we show that the MRE11 checkpoint protein is arginine methylated by PRMT1. Mutation of the arginines within MRE11 severely impaired the exonuclease activity of MRE11 but did not influence its ability to form complexes with RAD50 and NBS1. Cells containing hypomethylated MRE11 displayed...

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Topics

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Share to Acid Anhydride Hydrolases
Share to DNA Repair Enzymes
Share to Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MRE11 Homologue Protein

Share to Oligonucleotides

Share to Protein-Arginine N-Methyltransferases

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Share to Transduction, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 15741314
DOI: 10.1101/gad.1279805
PMCID: PMC1065720

Genes

MRE11
RAD50
PRMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control.PMID 15741314Read ↗

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