Article

Arginine Methylation Regulates SARS-CoV-2 Nucleocapsid Protein Function and Viral Replication

2021-03-24

Abstract excerpt

Viral proteins are known to be methylated by host protein arginine methyltransferases (PRMTs) playing critical roles during viral infections. Herein, we show that PRMT1 methylates SARS-CoV-2 nucleocapsid (N) protein at residues R95 and R177 within RGG/RG sequences. Arginine methylation of N protein was confirmed by immunoblotting viral proteins extracted from SARS-CoV-2 virions isolated by cell culture. We demonst...

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Literature Corpus work: f8e0c7ea-bd86-5ae0-a82f-d5735c83b444
DOI: 10.1101/2021.03.24.436822

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