Article
A role for the arginine methylation of Rad9 in checkpoint control and cellular sensitivity to DNA damage.
Nucleic acids research - 1 Jun 2011
He Wei, Ma Xiaoyan, Yang Xiao, Zhao Yun, Qiu Junkang, Hang Haiying
Abstract excerpt
The genome stability is maintained by coordinated action of DNA repairs and checkpoints, which delay progression through the cell cycle in response to DNA damage. Rad9 is conserved from yeast to human and functions in cell cycle checkpoint controls. Here, a regulatory mechanism for Rad9 function is reported. In this study Rad9 has been found to interact with and be methylated by protein arginine methyltransferase...
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