Article
A mouse PRMT1 null allele defines an essential role for arginine methylation in genome maintenance and cell proliferation.
Molecular and cellular biology - 1 Jun 2009
Yu Zhenbao, Chen Taiping, Hébert Josée, Li En, Richard Stéphane
Abstract excerpt
Protein arginine methyltransferase 1 (PRMT1) is the major enzyme that generates monomethylarginine and asymmetrical dimethylarginine. We report here a conditional null allele of PRMT1 in mice and that the loss of PRMT1 expression leads to embryonic lethality. Using the Cre/lox-conditional system, we show that the loss of PRMT1 in mouse embryonic fibroblasts (MEFs) leads to the loss of arginine methylation of...
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