Article
Longitudinal Analysis of HIV-2 Proviral DNA Reveals Archived Protease Inhibitor Resistance and Reservoir Evolution over Eight Years.
International journal of molecular sciences - 8 Jun 2026
Gonçalves Paloma, Lopes Inês, Martins Andreia, Maia Filipa, Martin Francisco, Borrego Pedro, Antunes Francisco, Valadas Emília, Palladino Claudia, Bártolo Inês, Taveira Nuno
Abstract excerpt
Protease inhibitors (PIs) remain important components of HIV-2 treatment, but resistance genotyping is frequently challenging in individuals with low or undetectable plasma viremia. Proviral DNA sequencing may provide access to archived viral variants and improve understanding of long-term resistance and clinical evolution. In this retrospective longitudinal study, 27 individuals with HIV-2, both ART-experienced...
Topics
- Humans
- HIV-2
- Drug Resistance, Viral
- HIV Infections
- Proviruses
- Longitudinal Studies
- Female
- DNA, Viral
- Viral Load
- HIV Protease Inhibitors
- Male
- HIV Protease
- Adult