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Article

HIV-1 virome profiling using HIV-PULSE to guide therapeutic and curative interventions.

EBioMedicine - 1 Jun 2026

De Braekeleer Sofie, Lambrechts Laurens, Termote Liesbet, Delporte Mareva, Mehta Kavita, Matzaraki Vasiliki, Blomme Evy E, Lemey Philippe, Vrancken Bram, Rokx Casper, Stalenhoef Janneke, Berrevoets Marvin A H, van der Ven Andre J, Gerlo Sarah, Rutsaert Sofie, Vandekerckhove Linos

Abstract excerpt

BACKGROUND: The persistent HIV-1 reservoir remains a major barrier to curing HIV-1, underscoring the need for a detailed understanding of its composition to inform targeted interventions. METHODS: Here, we apply the HIV Proviral Unique molecular identifier-mediated Long-read Sequencing (HIV-PULSE) assay to characterise the viral reservoir in 90 individuals on suppressive antiretroviral therapy. By generating near...

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Identifiers

PMID: 42167121
DOI: 10.1016/j.ebiom.2026.106297
PMCID: PMC13199670

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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