Article
Drug resistance and tropism as markers of the dynamics of HIV-1 DNA quasispecies in blood cells of heavily pretreated patients who achieved sustained virological suppression.
The Journal of antimicrobial chemotherapy - 1 Mar 2016
Gantner Pierre, Morand-Joubert Laurence, Sueur Charlotte, Raffi François, Fagard Catherine, Lascoux-Combe Caroline, Salmon Dominique, Amiel Corinne, Lambert-Niclot Sidonie, Fofana Djeneba Bocar, Viard Jean-Paul, Fafi-Kremer Samira, Rouzioux Christine, Avettand-Fenoel Véronique, Ghosn Jade
Abstract excerpt
OBJECTIVES: The objective of this study was to address the dynamics of archived resistant quasispecies in cell-associated HIV-1 DNA over time in heavily ART-experienced patients with currently suppressed plasma HIV-1 RNA. METHODS: Longitudinal ultra-deep sequencing (UDS) analysis of reverse transcriptase, protease and V3 Env regions was performed on blood-cell-associated HIV-1 DNA samples....
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