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The Enigmatic Tumor Suppressor p53 Biomolecule: Its Role and Prognostic and Predictive Values in Cancer Therapy and Precision Medicine.

Biomolecules - 28 May 2026

Siddik Zahid Hussain

Abstract excerpt

The p53 biomolecule is critical for facile antitumor response in cancer therapy. Once fully activated, p53 will kill tumor cells by activating programmed cell death (PCD), such as apoptosis and ferroptosis, and inducing immunogenic cell death. It is not surprising, therefore, that in about 50% of cancers p53 is mutated and non-functional, which induces drug resistance. Paradoxically, many cancers harboring the...

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Identifiers

PMID: 42352266
DOI: 10.3390/biom16060800
PMCID: PMC13297438

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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