p53: A tale of complexity and context.

doi:10.1016/j.cell.2024.02.043

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Article

p53: A tale of complexity and context.

Cell - 28 Mar 2024

Oren Moshe, Prives Carol

Abstract excerpt

The story of p53 is illuminating. Despite widespread attention, the tumor-suppressive functions of wild-type p53 or the oncogenic activities of its cancer-associated mutants are still not fully understood, and our discoveries have not yet led to major therapeutic breakthroughs. There is still much to learn about this fascinating protein.

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PMID: 38552605
DOI: 10.1016/j.cell.2024.02.043

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