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Recent findings on the role of wild-type and mutant p53 in cancer development and therapy

26 Sept 2022

Abstract excerpt

The p53 protein is a tumor suppressor encoded by the TP53 gene and consists of 393 amino acids with four main functional domains. This protein responds to various cellular stresses to regulate the expression of target genes, thereby causing DNA repair, cell cycle arrest, apoptosis, metabolic changes, and aging. Mutations in the TP53 gene and the functions of the wild-type p53 protein (wtp53) have been linked to...

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PMID: 36225257
DOI: 10.3389/fmolb.2022.903075

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