Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rescuing the function of mutant p53.

Nature reviews. Cancer - 1 Oct 2001

Bullock A N, Fersht A R

Abstract excerpt

One protein--p53--plays nemesis to most cancers by condemning damaged cells to death or quarantining them for repair. But the activity of p53 relies on its intact native conformation, which can be lost following mutation of a single nucleotide. With thousands of such mutations identified in patie...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzamides
Share to DNA
Share to Imatinib Mesylate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Piperazines

Share to Protein Folding

Share to Pyrimidines

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 11900253
DOI: 10.1038/35094077

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11900253-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rescuing the function of mutant p53.PMID 11900253Read ↗

Drug discovery and mutant p53.Semantic proximity Read ↗

p53 mutants: the achilles' heel of human cancers?Semantic proximity Read ↗

The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches.Semantic proximity Read ↗

p53—A Natural Cancer Killer: Structural Insights and Therapeutic ConceptsSemantic proximity Read ↗

Strategies for manipulating the p53 pathway in the treatment of human cancer.Semantic proximity Read ↗

Targeting mutant p53 in cancer: from mechanistic insights to therapeutic strategies.Semantic proximity Read ↗

Side-Stepping the Guardian of the Genome: Current Cancer Therapeutics Targeting Mutant p53Semantic proximity Read ↗

Unraveling the Guardian: p53's Multifaceted Role in the DNA Damage Response and Tumor Treatment Strategies.Semantic proximity Read ↗

Targeting Mutated p53: Naivete and Enthusiasm to Attempt the Impossible.Semantic proximity Read ↗

Structural biology of the tumor suppressor p53.Semantic proximity Read ↗

p53: A tale of complexity and context.Semantic proximity Read ↗

Structural biology of the tumor suppressor p53 and cancer-associated mutants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.