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Article

The moderation of genetic risk for ten major psychiatric and substance use disorders by the genetic aptitude for educational attainment.

Molecular psychiatry - 1 Jul 2025

Kendler Kenneth S, Ohlsson Henrik, Sundquist Jan, Sundquist Kristina

Abstract excerpt

We seek to clarify the impact of the Genetic Aptitude for Educational Attainment (GAEA) on risk for 10 psychiatric disorders divided into 4 groups: Internalizing, Externalizing, Eating/Compulsive and Psychotic. Educational attainment and psychiatric and substance use disorder information were obtained from national Swedish registries. GAEA and disorder-specific family genetic risk score (FGRS) were calculated...

Read the complete abstract on PubMed

Topics

Humans
Male
Substance-Related Disorders
Female
Genetic Predisposition to Disease
Adult

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mental Disorders

Educational Status

Sweden

Registries

Risk Factors

Intelligence

Aptitude

Middle Aged

Adolescent

Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 40247129
DOI: 10.1038/s41380-025-03022-z
PMCID: PMC12185330

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